circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-124-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: H1299, H838, PC-9, HCC-827, H-1650, H1975, A549
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: STAT3, PRKAA, AMPKalpha
Associated microRNA: hsa-miR-124-3p
Biological function: promote the proliferation, migration and invasion
Molecular mechanism: regulate MIR124-3p-STAT3-PRKAA/AMPKalpha signaling
Survival: -
Supported No.:
 4
Description:

These results support that circHIPK3 is a key autophagy regulator in a subset of lung cancer and has potential clinical use as a prognostic factor. The circular RNA HIPK3(circHIPK3) functions as an oncogene and autophagy regulator may potential use as a prognostic marker and therapeutic target in lung cancer.
Other information
Title:

Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPKalpha signaling in STK11 mutant lung cancer.

Journal: Autophagy
Published: 2019/6/25
PubMed ID: 31232177