circRNA basic information
circBase ID: -
Name: hsa_circ_PTPRA
Synonym: circPTPRA
Host Gene: hsa-miR-96-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cell lines (H23, H1755, H522), non-cancerous lung cell line (BEAS-2B)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-96-5p
Biological function: suppresses epithelial-mesenchymal transitioning and metastasis
Molecular mechanism: circPTPRA suppressed EMT in NSCLC cell lines and reduced metastasis in the murine xenograft model by sequestering hsa-miR-96-5p and upregulating RASSF8.
Survival: better
Supported No.:
 1
Description:

circPTPRA suppresses EMT and metastasis of NSCLC cell lines by sponging miR-96-5p, which upregulates the downstream tumor suppressor RASSF8. The circPTPRA/miR-96-5p/RASSF8/E-cadherin axis can be leveraged as a potential treatment avenue in NSCLC.
Other information
Title:

The circRNA circPTPRA suppresses epithelial-mesenchymal transitioning and metastasis of NSCLC cells by sponging miR-96-5p.

Journal: EBioMedicine
Published: 2019/6/5
PubMed ID: 31160270