circRNA basic information
circBase ID: hsa_circ_0025202
Name: hsa_circ_GAPDH
Synonym: circRNA_0025202
Host Gene: hsa-miR-182-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: BC cell lines (MCF7, T47D), HEK293T cells
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: FOXO3a
Associated microRNA: hsa-miR-182-5p
Biological function: inhibit cell proliferation, colony formation, and migration and increase cell apoptosis and sensitivity to tamoxifen
Molecular mechanism: act as a miRNA sponge for hsa-miR-182-5p and further regulate the expression and activity of FOXO3a
Survival: -
Supported No.:
 2
Description:

hsa_circ_0025202 served an anti-oncogenic role in HR-positive breast cancer, and it could be exploited as a novel marker for tamoxifen-resistant breast cancer.
Other information
Title:

circRNA_0025202 Regulates Tamoxifen Sensitivity and Tumor Progression via Regulating the miR-182-5p/FOXO3a Axis in Breast Cancer.

Journal: Mol Ther
Published: 2019/6/4
PubMed ID: 31153828