circRNA basic information
circBase ID: -
Name: hsa_circ_ZFR
Synonym: -
Host Gene: hsa-miR-511
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cell lines (HepG2, Bel-7402, SMMC-7721, Huh-7), human normal hepatic cell (WRL-68)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AKT1
Associated microRNA: hsa-miR-511
Biological function: promotes cell proliferation and migration
Molecular mechanism: directly down-regulating hsa-miR-511 to activate AKT1 signaling
Survival: -
Supported No.:
 4
Description:

circZFR promotes HCC progression by directly down-regulating miR-511 to activate AKT1 signaling, suggesting that circZFR is a potential target in HCC treatment.
Other information
Title:

circZFR promotes cell proliferation and migration by regulating miR-511/AKT1 axis in hepatocellular carcinoma.

Journal: Dig Liver Dis
Published: 2019/5/31
PubMed ID: 31147216