circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-1270
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human bladder cancer cell lines (TCCSUP, 5367, T24, EJ)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DS
Associated gene: APAF1
Associated microRNA: hsa-miR-1270
Biological function: as sensitizes bladder cancer to cisplatin
Molecular mechanism: upregulating APAF1 expression through hsa-miR-1270 inhibition
Survival: -
Supported No.:
 2
Description:

Cdr1as exerts a cisplatin-chemosensitization effect on bladder cancer cells through the Cdr1as/miR-1270/APAF1 axis.
Other information
Title:

Circular RNA Cdr1as sensitizes bladder cancer to cisplatin by upregulating APAF1 expression through miR-1270 inhibition.

Journal: Mol Oncol
Published: 2019/5/28
PubMed ID: 31131537