| Description: |
In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN6 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels. |