circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF264
Synonym: -
Host Gene: hsa-miR-4493
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: cell line
Sample type details: human normal astrocytes, glioma cell line (U251, LN18, A172, T98G, LN229)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-4493
Biological function: promoted cell proliferation and invasion and inhibited apoptosis.
Molecular mechanism: Upregulating the Expression of hsa-miR-4493 Target Gene Apelin
Survival: -
Supported No.:
 1
Description:

In glioma cells, circ-ZNF264 can inhibit the function of miR-4493 and then upregulate its target gene apelin expression, thus regulating glioma cell proliferation, apoptosis, and invasion.
Other information
Title:

Circ-ZNF264 Promotes the Growth of Glioma Cells by Upregulating the Expression of miR-4493 Target Gene Apelin.

Journal: J Mol Neurosci
Published: 2019/5/23
PubMed ID: 31114952