circRNA basic information
circBase ID: hsa_circ_0009361
Name: hsa_circ_GNB1
Synonym: -
Host Gene: hsa-miR-582
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal colonic epithelial cells (NCM460), CRC cell lines (HT29, SW480, HCT-116, SW620, Lovo, SW48, DLD-1, Caco-2, HCT-15)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: APC2
Associated microRNA: hsa-miR-582
Biological function: suppress the growth and metastasis
Molecular mechanism: acted as a tumor suppressive sponge of hsa-miR-582, which could up-regulate the expression of APC2, inhibit the Wnt/beta-catenin signaling
Survival: -
Supported No.:
 1
Description:

Hsa_circ_0009361 acted as a tumor suppressive sponge of miR-582, which could up-regulate the expression of APC2, inhibit the Wnt/beta-catenin signaling, and suppress the growth and metastasis of CRC.
Other information
Title:

Hsa_circ_0009361 acts as the sponge of miR-582 to suppress colorectal cancer progression by regulating APC2 expression.

Journal: Clin Sci (Lond)
Published: 2019/5/22
PubMed ID: 31109967