circRNA basic information
circBase ID: -
Name: hsa_circ_VANGL1
Synonym: -
Host Gene: hsa-miR-195
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NSCLC cell lines (A549, H1299, H1975, SPC-A1, SK-MES-1), normal human bronchial epithelial cell line (16HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Bcl-2
Associated microRNA: hsa-miR-195
Biological function: facilitate the growth, migration, and invasion and inhibit cell apoptosis
Molecular mechanism: might serve as a competing endogenous RNA (ceRNA), becoming a sink for hsa-miR-195, thereby modulating the expression of Bcl-2
Survival: -
Supported No.:
 1
Description:

we conclude that circVANGL1 functions as an oncogene to promote NSCLC progression partly through miR-195/Bcl-2 axis.
Other information
Title:

Up-regulated circular RNA VANGL1 contributes to progression of non-small cell lung cancer through inhibition of miR-195 and activation of Bcl-2.

Journal: Biosci Rep
Published: 2019/5/12
PubMed ID: 31076544