circRNA basic information
circBase ID: hsa_circ_0004381
Name: -
Synonym: circ_0004381
Host Gene: hsa-miR-647
 
 
 
Disease basic information
DO ID:
 10652
DO name: Alzheimer disease
Disease details: Alzheimer disease
Species: human
Species details: human
Sample type: cell line
Sample type details: BV2
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PSEN1
Associated microRNA: hsa-miR-647
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

knockdown of circ_0004381 attenuated hippocampal neuronal damage and promoted microglia M2-type polarization through the miR-647/PSEN1 axis, ultimately improving cognitive function in AD model mice.
Other information
Title:

Inhibition of circ_0004381 improves cognitive function via miR-647/PSEN1 axis in an Alzheimer disease mouse model.

Journal: J Neuropathol Exp Neurol
Published: 2022/11/22
PubMed ID: 36409993