circRNA basic information
circBase ID: -
Name: hsa_circ_P4HB
Synonym: circP4HB
Host Gene: hsa-miR-133a-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: BEAS-2B, H23, H1755, H522, non-cancerous lung cell line BEAS-2B
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-133a-5p
Biological function: promotes NSCLC aggressiveness and metastasis
Molecular mechanism: targeting the circP4HB/hsa-miR-133a-5p/vimentin axis
Survival: poor
Supported No.:
 2
Description:

circP4HB enhances EMT and metastatic disease through miR-133a-5p sequestration, leading to upregulation of vimentin.
Other information
Title:

The circRNA circP4HB promotes NSCLC aggressiveness and metastasis by sponging miR-133a-5p.

Journal: Biochem Biophys Res Commun
Published: 2019/4/22
PubMed ID: 31005252