circRNA basic information
circBase ID: -
Name: hsa_circ_MAT2B
Synonym: -
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCC cell lines (HepG2, Huh7, SMMC7721, Focus, MHCC-97L, MHCC-97H)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PKM2
Associated microRNA: hsa-miR-338-3p
Biological function: promotes Glycolysis and Malignancy
Molecular mechanism: circMAT2B up-regulated expression levels of the microRNA (miR)-338-3p target gene PKM2, which encodes a key enzyme in the process of glycolysis, through sponging hsa-miR-338-3p
Survival: -
Supported No.:
 1
Description:

circMAT2B promoted HCC progression by enhanced glycolysis by activating the circMAT2B/miR-338-3p/PKM2 axis under hypoxia, which may provide a therapeutic target for HCC.
Other information
Title:

Circular RNA MAT2B Promotes Glycolysis and Malignancy of Hepatocellular Carcinoma Through the miR-338-3p/PKM2 Axis Under Hypoxic Stress.

Journal: Hepatology
Published: 2019/4/21
PubMed ID: 31004447