circRNA basic information
circBase ID: -
Name: hsa_circ_RAD18
Synonym: -
Host Gene: hsa-miR-208a, hsa-miR-3164
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human breast cancer immortalized cell lines (MDA-MB-231, MDA-MB-468, BT549, HCC38, HCC1806, MCF-7, T47D, MDA-MB-453, BT474, Skbr-3), normal mammary epithelial cell lines (MCF-10A), HEK 293T
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF1, FGF2
Associated microRNA: hsa-miR-208a, hsa-miR-3164
Biological function: facilitated cell proliferation and migration and inhibit cell apoptosis
Molecular mechanism: acts as a sponge of hsa-miR-208a and hsa-miR-3164 and promotes TNBC progression through upregulating IGF1 and FGF2 expression.
Survival: poor
Supported No.:
 1
Description:

our research revealed the pivotal role of circRAD18-miR-208a/3164-IGF1/FGF2 axis in TNBC tumorigenesis and metastasis though the mechanism of competing endogenous RNAs.
Other information
Title:

circRAD18 sponges miR-208a/3164 to promote triple-negative breast cancer progression through regulating IGF1 and FGF2 expression.

Journal: Carcinogenesis
Published: 2019/4/20
PubMed ID: 31001629