circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF652
Synonym: -
Host Gene: hsa-miR-203, hsa-miR-502-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cell lines (HepG2, Huh7, SMMC7721, HCCLM3, SK-HEP-1), human normal liver cell line (LO2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Snail
Associated microRNA: hsa-miR-203, hsa-miR-502-5p
Biological function: promotes hepatocellular carcinoma metastasis
Molecular mechanism: circ-ZNF652 could physically interact with hsa-miR-203 and hsa-miR-502-5p to increase the expression of their common target gene Snail (a key transcription factor that triggers EMT),
Survival: -
Supported No.:
 2
Description:

our findings suggest that circ-ZNF652 is a novel driver of EMT and unveil the important regulatory role of circ-ZNF652/miR-203/miR-502-5p/Snail feedback loop in HCC metastasis.
Other information
Title:

A novel circular RNA circ-ZNF652 promotes hepatocellular carcinoma metastasis through inducing snail-mediated epithelial-mesenchymal transition by sponging miR-203/miR-502-5p.

Journal: Biochem Biophys Res Commun
Published: 2019/4/20
PubMed ID: 31000195