circRNA basic information
circBase ID: hsa_circ_0004339
Name: hsa_circ_DONSON
Synonym: circ-DONSON
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: GC cell lines (BGC-823, AGS, MGC-803, MKN74, HGC-27, SGC-7901), normal human gastric epithelial cell line (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SOX4
Associated microRNA: -
Biological function: facilitates gastric cancer growth and invasion
Molecular mechanism: circ-DONSON was localized in the nucleus, recruited the NURF complex to SOX4 promoter and initiated its transcription.
Survival: -
Supported No.:
 3
Description:

The circ-DONSON promotes GC progression through recruiting the NURF complex to initiate SOX4 expression.
Other information
Title:

Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation of transcription factor SOX4.

Journal: Mol Cancer
Published: 2019/3/30
PubMed ID: 30922402