circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-7
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: BC cell lines (MCF_7, SKBR_3, MDA_MB_231, HCC_1937), normal mammary epithelial cells (MCF10)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CCNE1
Associated microRNA: hsa-miR-7
Biological function: reduce chemosensitivity
Molecular mechanism: inhibiting hsa-miR-7 to regulate CCNE1
Survival: -
Supported No.:
 2
Description:

CDR1as may regulate chemosensitivity of 5-FU-resistant BC cells by inhibiting miR-7 to regulate CCNE1.
Other information
Title:

Inhibition of circular RNA CDR1as increases chemosensitivity of 5-FU-resistant BC cells through up-regulating miR-7.

Journal: J Cell Mol Med
Published: 2019/3/19
PubMed ID: 30884120