circRNA basic information
circBase ID: -
Name: hsa_circ_FOXO3
Synonym: -
Host Gene: hsa-miR-22, hsa-miR-136*, hsa-miR-138, hsa-miR-149*, hsa-miR-433, hsa-miR-762, hsa-miR-3614-5p, hsa-miR-3622b-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-22, hsa-miR-136*, hsa-miR-138, hsa-miR-149*, hsa-miR-433, hsa-miR-762, hsa-miR-3614-5p, hsa-miR-3622b-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 3
Description:

The breast tumor tissues expressed low levels of circ-Foxo3, Foxo3P and Foxo3 compared with normal tissues. We found that the ectopic expression of the Foxo3P, Foxo3 circular RNA and Foxo3 mRNA could all suppress tumor growth and cancer cell proliferation and survival.
Other information
Title:

Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis.

Journal: Oncogene
Published: 2015/12/15
PubMed ID: 26657152