circRNA basic information
circBase ID: hsa_circ_0001681
Name: hsa_circ_RAPGEF5
Synonym: circRAPGEF5
Host Gene: hsa-miR-198
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human thyroid normal cell line (Nthy-ori 3-1), PTC cell lines (BCPAP, KTC-1, K1, HEK293)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FGFR1
Associated microRNA: hsa-miR-198
Biological function: contributes to Papillary Thyroid Proliferation and Metastatis
Molecular mechanism: Regulation hsa-miR-198/FGFR1
Survival: -
Supported No.:
 1
Description:

The circRAPGEF5 acts as a tumor promoter via a novel circRAPGEF5/miR-198/FGFR1 axis, providing a potential biomarker and therapeutic target for the management of PTC.
Other information
Title:

circRAPGEF5 Contributes to Papillary Thyroid Proliferation and Metastatis by Regulation miR-198/FGFR1.

Journal: Mol Ther Nucleic Acids
Published: 2019/2/21
PubMed ID: 30785065