circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: human WI-38 fibroblasts, MCF7 breast carcinoma cells, IMR-90 lung fibroblasts
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF2BP1, KRAS and HMGA2, let-7
Associated microRNA: -
Biological function: promoted proliferation
Molecular mechanism: -
Survival: -
Supported No.:
 4
Description:

Our findings indicate that the SAC-RNA CircPVT1, elevated in dividing cells and reduced in senescent cells, sequesters let-7 to enable a proliferative phenotype.
Other information
Title:

Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1.

Journal: Nucleic Acids Res
Published: 2016/12/9
PubMed ID: 27928058