Description: |
The ceRNA regulatory network analysis showed that hsa_circ_0059655 and other 14 circRNAs derived from PYGB target on several similar genes by miR-338-3p. Among the 15 circRNAs derived from PYGB, hsa_circ_0059655 has the most relationships in the ceRNA network. Furthermore, after hsa_circ_0059655 was knocked down in SACC-83 cells, the expression of hsa-miR-338-3p was up-regulated while CCND1 was down-regulated. The proliferation, migration, and invasion of SACC-83 cells also decreased after hsa_circ_0059655 knock-downed. |