circRNA basic information
circBase ID: -
Name: hsa_circ_NSD2
Synonym: circ-NSD2
Host Gene: hsa-miR-199b-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human colon cancer cell lines (HCT116, SW480, RKO, LoVo, DLD-1, HT-29)
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: DDR1, JAG1
Associated microRNA: hsa-miR-199b-5p
Biological function: promoted migration and metastasis
Molecular mechanism: suppressor hsa-miR-199b-5p and activated DDR1 (discoidin domain receptor tyrosine kinase 1) and JAG1 (Jagged 1) genes
Survival: -
Supported No.:
 1
Description:

Our findings highlight a novel oncogenic function of circ-NSD2 and uncover a key mechanism for the circ-NSD2/miR-199b-5p/DDR1/JAG1 axis in CRC metastasis, which may serve as a prognostic factor and therapeutic target for antimetastatic therapy in CRC patients.
Other information
Title:

NSD2 circular RNA promotes metastasis of colorectal cancer by targeting miR-199b-5p-mediated DDR1 and JAG1 signalling.

Journal: J Pathol
Published: 2019/1/23
PubMed ID: 30666650