circRNA basic information
circBase ID: hsa_circ_0011385
Name: hsa_circ_EIF3I
Synonym: circRNA 100146
Host Gene: hsa-miR-361-3p, hsa-miR-615-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: lung cancer cell lines (A549, H446, H1299, 95-D, H460), normal human bronchial epithelial cell line (16HBE), malignantly transformed cell line (16HBE-T)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-361-3p, hsa-miR-615-5p
Biological function: promoted proliferation and invasion while inhibits apoptosis
Molecular mechanism: direct binding to hsa-miR-361-3p and hsa-miR-615-5p
Survival: -
Supported No.:
 1
Description:

Our collective findings support a role of circRNA 100146 in the development of NSCLC and further demonstrate endogenous competition among circRNA 100146, SF3B3 and miRNAs, providing novel insights into the mechanisms underlying non-small cell lung cancer.
Other information
Title:

Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer.

Journal: Mol Cancer
Published: 2019/1/23
PubMed ID: 30665425