circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: circ_0001946
Host Gene: hsa-miR-671-5p
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: cell line
Sample type details: glioma cell lines (U87, U251), human microglia (HM)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: CDR1
Associated microRNA: hsa-miR-671-5p
Biological function: reduced proliferation, migration, and invasion and increased apoptosis
Molecular mechanism: modulating hsa-miR-671-5p and CDR1
Survival: -
Supported No.:
 2
Description:

Our study confirmed that the circ_0001946/miR-671-5p/ CDR1 pathway modulates the development of GBM, and this pathway might be a promising target for the development of therapeutics for GBM.
Other information
Title:

Circular RNA circ_0001946 acts as a competing endogenous RNA to inhibit glioblastoma progression by modulating miR-671-5p and CDR1.

Journal: J Cell Physiol
Published: 2019/1/22
PubMed ID: 30663767