circRNA basic information
circBase ID: hsa_circ_0085154
Name: hsa_circ_ARSP91
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NK-92MI cells, HCC tumor cell lines (SK-Hep1, MHCC-97H)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: ULBP1
Associated microRNA: -
Biological function: enhances the cytotoxicity of natural killer cells
Molecular mechanism: upregulating UL16 binding protein 1.
Survival: -
Supported No.:
 2
Description:

In conclusion, CircARSP91 could enhance innate immune surveillance by strengthening the cytotoxicity of NK cells, implying that circRNA may serve a role in tumor immunity.
Other information
Title:

circRNA of AR-suppressed PABPC1 91 bp enhances the cytotoxicity of natural killer cells against hepatocellular carcinoma via upregulating UL16 binding protein 1.

Journal: Oncol Lett
Published: 2019/1/19
PubMed ID: 30655779