circRNA basic information
circBase ID: hsa_circ_0000817
Name: hsa_circ_FOXK2
Synonym: circFOXK2
Host Gene: hsa-miR-484
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human hepatocyte line (LO2), four human HCC lines (Huh7, HepG2, Hep3B, SK-Hep1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Fis1
Associated microRNA: hsa-miR-484
Biological function: Silencing of circFOXK2 significantly suppressed HCC progression both in vitro and in vivo
Molecular mechanism: circFOXK2/hsa-miR-484/Fis1 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

circFOXK2 upregulated the expression of protein FOXK2-142aa to promote LDHA phosphorylation and led to mitochondrial fission by regulating the miR-484/Fis1 pathway, ultimately activating the Warburg effect in HCC.
Other information
Title:

CircFOXK2 promotes hepatocellular carcinoma progression and leads to a poor clinical prognosis via regulating the Warburg effect.

Journal: J Exp Clin Cancer Res
Published: 2023/3/17
PubMed ID: 36922872