circRNA basic information
circBase ID: -
Name: -
Synonym: MCF7_circ_000595
Host Gene: -
 
 
 
Disease basic information
DO ID:
1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: breast cancer cell lines (BT20, BT474, MCF7, MDAMB468, T47D, ZR751), one cell line derived from normal breast cells (MCF10A)
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
1
Description:

This circRNA was found at chr14:102,466,325_102,500,789 and had 12 supporting junction-spanning reads. This circRNA was a spliced product of gene DYNC1H1 and spanned from exons 17 to 56 of the gene. Considering that the exon-intron structure remains intact, the size of this circRNA is about 7 kb and may play a role in post-transcriptional regulation. Notably, the circRNA contained microRNA response elements (MRE) for miR-150 and miR-661 with 29 and 23 unique binding sites respectively. These two microRNAs have been previously reported to have associations with cancer.

Other information
Title:

Circular RNAs and their associations with breast cancer subtypes.

Journal: Oncotarget
Published: 2016/11/10
PubMed ID: 27829232