circRNA basic information
circBase ID: -
Name: hsa_circ_DICER1
Synonym: circ-DICER1
Host Gene: hsa-miR-103a-3p, hsa-miR-382-5p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human glioma cell lines (U87MG), human embryonic kidney 293 T cell lines (HEK293T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ZIC4
Associated microRNA: hsa-miR-103a-3p, hsa-miR-382-5p
Biological function: promotes the cell viability, migration, and tube formation
Molecular mechanism: MOV10 binding circ-DICER1 regulated the cell viability, migration, and tube formation of GECs. And the effects of both MOV10 and circ-DICER1 silencing were better than the effects of MOV10 or circ-DICER1 alone silencing. In addition, circ-DICER1 acts as a molecular sponge to adsorb hsa-miR-103a-3p / hsa-miR-382-5p and impair the negative regulation of hsa-miR-103a-3p / hsa-miR-382-5p on ZIC4 in GECs. Furthermore, ZIC4 up-regulates the expression of its downstream target Hsp90beta, and Hsp90 promotes the cell viability, migration, and tube formation of GECs by activating PI3K/Akt signaling pathway.
Survival: -
Supported No.:
 1
Description:

MOV10 / circ-DICER1 / miR-103a-3p (miR-382-5p) / ZIC4 pathway plays a vital role in regulating the angiogenesis of glioma. Our findings not only provides novel mechanisms for the angiogenesis of glioma, but also provide potential targets for anti-angiogenesis therapies of glioma.
Other information
Title:

MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change.

Journal: J Exp Clin Cancer Res
Published: 2019/1/10
PubMed ID: 30621721