circRNA basic information
circBase ID: -
Name: gga_circ_Vav3
Synonym: circ-Vav3
Host Gene: gga-miR-375
 
 
 
Disease basic information
DO ID:
 3571
DO name: liver cancer
Disease details: liver tumors
Species: chicken
Species details: chicken
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: YAP1
Associated microRNA: gga-miR-375
Biological function: -
Molecular mechanism: sponges gga-miR-375 to promote epithelial-mesenchymal transition
Survival: -
Supported No.:
 1
Description:

In this study, circRNA sequencing results revealed that a circRNA Vav3 termed circ-Vav3 was upregulated in the liver tumors of chickens infected with ALV-J. We further confirmed that the circ-Vav3/gga-miR-375/YAP1 axis induces epithelial-mesenchymal transition (EMT) through influencing EMT markers to promote tumorigenesis.
Other information
Title:

Circular RNA Vav3 sponges gga-miR-375 to promote epithelial-mesenchymal transition.

Journal: RNA Biol
Published: 2019/1/5
PubMed ID: 30608205