circRNA basic information
circBase ID: hsa_circ_0002211
Name: hsa_circ_DDX17
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human CRC cell lines (SW480, SW620, HT29, LoVo, HCT116, RKO)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: inhibited proliferation, migration, invasion, and promote apotosis
Molecular mechanism: -
Survival: -
Supported No.:
 2
Description:

The results of qRT-PCR for circDDX17 in 60 paired CRC tissues showed that circDDX17 was significantly down-regulated in CRC tissues and associated with unfavorable clinicopathological parameters. In vitro experiments showed that silencing of circDDX17 promoted CRC cell proliferation, migration, invasion, and inhibited apoptosis.
Other information
Title:

RNA sequencing reveals the expression profiles of circRNA and indicates that circDDX17 acts as a tumor suppressor in colorectal cancer.

Journal: J Exp Clin Cancer Res
Published: 2018/12/29
PubMed ID: 30591054