circRNA basic information
circBase ID: hsa_circ_0085553
Name: hsa_circ_PVT1
Synonym: circPVT1
Host Gene: hsa-miR-497
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human NSCLC cell lines (H1299, H1650, A549, PC9, SK-MES-1), normal human bronchial epithelial cell line (16HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: BCL2
Associated microRNA: hsa-miR-497
Biological function: promoted cell proliferation while inhibits apoptosis
Molecular mechanism: targeting hsa-miR-497
Survival: poor
Supported No.:
 2
Description:

We firstly found that circPVT1 was overexpressed in clinical NSCLC tissues and cell lines. NSCLC patients with high expression of circPVT1 exhibited aggressive clinicopathological characteristics and poor prognosis. In vitro assays of the NSCLC cell lines (H1299 and A549 cells) demonstrated that knockdown of circPVT1 inhibited NSCLC cell proliferation and induced NSCLC cell apoptosis. We further found that circPVT1 served as a competing endogenous RNA of miR-497 and indirectly regulated Bcl-2 expression in NSCLC cells. Finally, inhibition of miR-497 abrogated the effects of circPVT1 knockdown in NSCLC cells.
Other information
Title:

Circular RNA PVT1 acts as a competing endogenous RNA for miR-497 in promoting non-small cell lung cancer progression.

Journal: Biomed Pharmacother
Published: 2018/12/28
PubMed ID: 30590312