circRNA basic information
circBase ID: hsa_circ_0000263
Name: hsa_circ_TCONS_00017720
Synonym: -
Host Gene: hsa-miR-150-5p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal cervical epithelial cell line (HcerEpic), cervical cancer cell lines (HeLa, CaSki, SiHa, C_33A, SW756)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: MDM4
Associated microRNA: hsa-miR-150-5p
Biological function: promoted cell proliferation, migration
Molecular mechanism: hsa_circ_0000263/hsa-miR-150-5p/MDM4/p53 regulatory network
Survival: -
Supported No.:
 2
Description:

We found that hsa_circ_0000263 was significantly upregulated in cervical cancer cells. In addition, the knockdown of hsa_circ_0000263, would inhibit cell proliferation and migration ability. In conclusion, our current research reveals the important role of hsa_circ_0000263/miR-150-5p/MDM4/p53 regulatory network in cervical cancer and provides a new insight into the pathogenesis of cervical cancer.
Other information
Title:

Circular RNA hsa_circ_0000263 participates in cervical cancer development by regulating target gene of miR-150-5p.

Journal: J Cell Physiol
Published: 2018/12/21
PubMed ID: 30569515