circRNA basic information
circBase ID: hsa_circ_0123778
Name: hsa_circ_CTNNB1
Synonym: circ-CTNNB1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 162
DO name: cancer
Disease details: cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human embryonic kidney cells (HEK293T), gastric cancer cell lines (MKN-45, AGS), cervical cancer (HeLa), prostate cancer (PC-3), breast cancer (MCF-7), colon cancer (HCT-116, LoVo), liver cancer (HepG2), neuroblastoma (SH-SY5Y)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: DDX3, YY1
Associated microRNA: -
Biological function: promote activation, growth, invasion, and metastasis
Molecular mechanism: regulating DDX3-Mediated Transactivation of YY1
Survival: poor
Supported No.:
 1
Description:

Circ-CTNNB1 was predominantly expressed in the nucleus, upregulated in cancer tissues and cell lines, and associated with unfavorable outcomes in patients with cancer.
Other information
Title:

Cis-Acting circ-CTNNB1 Promotes beta-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1.

Journal: Cancer Res
Published: 2018/12/20
PubMed ID: 30563889