circRNA basic information
circBase ID: -
Name: hsa_circ_MTO1
Synonym: -
Host Gene: hsa-miR-221
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal bladder epithelial cells (CCC-HB-2), bladder cancer cell lines (UMUC3, SVHUC1, T24, J82, 5637)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-221
Biological function: inhibited cells epithelial-to-mesenchymal transition (EMT) and metastasis
Molecular mechanism: sponge hsa-miR-221 and overexpression of circMTO1 negatively regulated the E-cadherin/N-cadherin pathway
Survival: better
Supported No.:
 1
Description:

Our findings provide comprehensive evidences that circMTO1 is a prognostic biomarker in bladder cancer and suggest that circMTO1 may function as a novel therapeutic target in human bladder cancer.
Other information
Title:

Circular RNA circMTO1 suppresses bladder cancer metastasis by sponging miR-221 and inhibiting epithelial-to-mesenchymal transition.

Journal: Biochem Biophys Res Commun
Published: 2018/12/16
PubMed ID: 30551873