circRNA basic information
circBase ID: -
Name: hsa_circ_DB
Synonym: circ-DB
Host Gene: hsa-miR-34a
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human hepatocellular adenocarcinoma (HepG2), mouse hepatocellular adenocarcinoma (Hepa 1-6), 3T3L1 cell lines
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: USP7, Cyclin A2
Associated microRNA: hsa-miR-34a
Biological function: promotes the growth of hepatocellular carcinoma
Molecular mechanism: suppressing hsa-miR-34a and activating the USP7/Cyclin A2 signaling pathway
Survival: -
Supported No.:
 1
Description:

exosome circRNAs secreted from adipocytes promote tumor growth and reduce DNA damage by suppressing miR-34a and activating the USP7/Cyclin A2 signaling pathway.
Other information
Title:

Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7.

Journal: Oncogene
Published: 2018/12/14
PubMed ID: 30546088