circRNA basic information
circBase ID: hsa_circ_0020014
Name: -
Synonym: circ_0020014
Host Gene: hsa-miR-613
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CHON-001 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ADAMTS5
Associated microRNA: hsa-miR-613
Biological function: IL-1beta treatment induced cell injury by promoting inflammation and apoptosis, and inhibiting cell viability and extracellular matrix (ECM) accumulation in chondrocytes. Circ_0020014 knockdown significantly protected CHON-001 cells from IL-1beta-induced cell dysfunction.
Molecular mechanism: MiR-613 was targeted by circ_0020014 and negatively regulated ADAMTS5 expression.
Survival: -
Supported No.:
 2
Description:

circ_0020014 acted as a miR-613 sponge to regulate ADAMTS5 expression, thereby protecting chondrocytes from IL-1beta-induced inflammatory damage, which might be a novel diagnostic marker for OA.
Other information
Title:

Circular RNA circ_0020014 contributes to osteoarthritis progression via miR-613/ADAMTS5 axis.

Journal: Bosn J Basic Med Sci
Published: 2022/3/1
PubMed ID: 35225755