circRNA basic information
circBase ID: -
Name: hsa_circ_FECR1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human breast cancer cell lines (MDA-MB231, MCF7, SKBR3, T47D, BT474, ZR751), viral packaging 293 T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TET1, DNMT1
Associated microRNA: -
Biological function: promotes metastasis
Molecular mechanism: coordinately regulating TET1 and DNMT1.
Survival: -
Supported No.:
 1
Description:

FECR1 circular RNA acts as an upstream regulator to control breast cancer tumor growth by coordinating the regulation of DNA methylating and demethylating enzymes. Thus, FLI1 drives tumor metastasis not only through the canonical oncoprotein pathway, but also by using epigenetic mechanisms mediated by its exonic circular RNA.
Other information
Title:

A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1.

Journal: Genome Biol
Published: 2018/12/13
PubMed ID: 30537986