circRNA basic information
circBase ID: -
Name: hsa_circ_LARP4
Synonym: -
Host Gene: hsa-miR-761
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human liver cell line (QSG-7701), HCC cell lines (Huh7, Hep3B, SMMC7721, HepG2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: RUNX3, p53, p21
Associated microRNA: hsa-miR-761
Biological function: suppressed HCC cell proliferation, mediated cell cycle arrest and induced senescence
Molecular mechanism: circLARP4 dampened HCC progression by sponging hsa-miR-761, thereby promoting the expression level of RUNX3 and activating the downstream p53/p21 signaling
Survival: better
Supported No.:
 1
Description:

The role of circLARP4/miR-761/RUNX3/p53/p21 signaling in HCC progression, providing a potential survival predictor and therapeutic candidate for HCC.
Other information
Title:

circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma.

Journal: Cancer Sci
Published: 2018/12/7
PubMed ID: 30520539