circRNA basic information
circBase ID: hsa_circ_0006528
Name: hsa_circ_PRELID2
Synonym: hsa_circRNA_0006528
Host Gene: hsa-miR-7-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: human breast cancer cell lines (BT-549, ZR-75-30, MDA-MB-231, MCF-7, BT-474, Hs578T, T-47D)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Raf1, MEK, ERK
Associated microRNA: hsa-miR-7-5p
Biological function: promotes breast cancer growth, invasion, and migration
Molecular mechanism: promoting the expression of Raf1 and activates the MAPK/ERK pathway
Survival: poor
Supported No.:
 4
Description:

This study provides the first evidence of the circ_0006528/miR-7-5p/Raf1/MEK/ERK regulatory network in the development of breast cancer and suggests that circ_0006528 is a potential therapeutic target and prognostic predictor for breast cancer.
Other information
Title:

hsa_circRNA_0006528 as a competing endogenous RNA promotes human breast cancer progression by sponging miR-7-5p and activating the MAPK/ERK signaling pathway.

Journal: Mol Carcinog
Published: 2018/12/7
PubMed ID: 30520151