circRNA basic information
circBase ID: -
Name: hsa_circ_MMP9
Synonym: -
Host Gene: hsa-miR-124
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: U87
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: eIF4A3
Associated microRNA: hsa-miR-124
Biological function: promoted the proliferation, migration and invasion abilities
Molecular mechanism: acts as a sponge of hsa-miR-124
Survival: -
Supported No.:
 1
Description:

Our findings indicate that eIF4A3-induced circMMP9 is an important underlying mechanism in GBM cell proliferation, invasion and metastasis through modulation of the miR-124 signaling pathway, which could provide pivotal potential therapeutic targets for the treatment of GBM.
Other information
Title:

EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis.

Journal: Mol Cancer
Published: 2018/11/25
PubMed ID: 30470262