circRNA basic information
circBase ID: -
Name: hsa_circ_ZFR
Synonym: -
Host Gene: hsa-miR-3619-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCC cell lines (MHCC97H, Hep3B, Huh7, Bel-7402)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: CTNNB1
Associated microRNA: hsa-miR-3619-5p
Biological function: promote cell proliferation and EMT
Molecular mechanism: enhanced the CTNNB1 expression via sponging hsa-miR-3619-5p
Survival: poor
Supported No.:
 4
Description:

Our findings indicated that circZFR may exert carcinogenic role in HCC through regulating miR-3619-5p/CTNNB1 axis and activating Wnt/beta-catenin pathway.
Other information
Title:

CircZFR promotes hepatocellular carcinoma progression through regulating miR-3619-5p/CTNNB1 axis and activating Wnt/beta-catenin pathway.

Journal: Arch Biochem Biophys
Published: 2018/11/24
PubMed ID: 30468709