circRNA basic information
circBase ID: hsa_circ_0007294
Name: hsa_circ_ANKS1B
Synonym: -
Host Gene: hsa-miR-152-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal breast epithelial cell line (MCF10A), breast cancer cell lines (MCF-7, T47D, SK-BR-3, MDA-MB-231, MDA-MB-468, BT549)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: USF1, TGF-beta1, Smad, ESRP1, USF1
Associated microRNA: hsa-miR-152-3p
Biological function: promoted breast cancer invasion and metastasis
Molecular mechanism: sponged hsa-miR-148a-3p and hsa-miR-152-3p to increase the expression of transcription factor USF1, which could transcriptionally up-regulate TGF-beta1 expression, resulting in activating TGF-beta1/Smad signaling to promote EMT
Survival: poor
Supported No.:
 1
Description:

circANKS1B abundantly sponged miR-148a-3p and miR-152-3p to increase the expression of transcription factor USF1, which could transcriptionally up-regulate TGF-beta1 expression, resulting in activating TGF-beta1/Smad signaling to promote EMT.

Other information
Title:

The pro-metastasis effect of circANKS1B in breast cancer.

Journal: Mol Cancer
Published: 2018/11/21
PubMed ID: 30454010