circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-7
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: OS cell lines (U2OS, MG63, 143B, HOS, Saos2), human osteoblastic cell line (hFOB1.19)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: EGFR, _CNE1, _I3KCD, RAF1
Associated microRNA: hsa-miR-7
Biological function: promoted cell proliferation while inhibits apoptosis
Molecular mechanism: CDR1as/hsa-miR-7 signal axis
Survival: poor
Supported No.:
 1
Description:

Inhibition of CDR1as in OS cell lines U2OS and MG63 with high CDR1as levels, leading to de-repressed miR-7 levels, impaired cell vitality and increased apoptosis and G1/S arrest in parallel with reduced ability of cell migration.
Other information
Title:

CircRNA CDR1as/miR-7 signals promote tumor growth of osteosarcoma with a potential therapeutic and diagnostic value.

Journal: Cancer Manag Res
Published: 2018/10/23
PubMed ID: 30425578