circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: cir-ITCH, circ-ITCH
Host Gene: hsa-miR-7, hsa-miR-214
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human lung cancer cell lines (A549, NCI-H460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: ITCH
Associated microRNA: hsa-miR-7, hsa-miR-214
Biological function: suppresses proliferation
Molecular mechanism: inhibiting Wnt nad beta-Catenin Pathway, miRNA sponge
Survival: -
Supported No.:
 1
Description:

cir-ITCH acted as sponge of oncogenic miR-7 and miR-214 to enhance ITCH expression and thus suppressed the activation of Wnt/beta-catenin signaling. cir-ITCH may play an inhibitory role in lung cancer progression by enhancing its parental gene, ITCH, expression.
Other information
Title:

Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/beta-Catenin Pathway.

Journal: Biomed Res Int
Published: 2016/9/20
PubMed ID: 27642589