circRNA basic information
circBase ID: -
Name: hsa_circ_PDSS1
Synonym: circPDSS1
Host Gene: hsa-miR-186-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human GC cell lines (MGC_803, HGC_27, BGC_823), normal gastric cell (GES_1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NEK2
Associated microRNA: hsa-miR-186-5p
Biological function: promoted GC cell cycle and inhibited apoptosis
Molecular mechanism: regulating hsa-miR-186-5p and NEK2
Survival: poor
Supported No.:
 2
Description:

Thus, circPDSS1 acts as a tumor promoter by regulating miR-186-5p and NEK2, which could be a potential biomarker and therapeutic target for the management of GC.
Other information
Title:

CircRNA circPDSS1 promotes the gastric cancer progression by sponging miR-186-5p and modulating NEK2.

Journal: J Cell Physiol
Published: 2018/11/13
PubMed ID: 30417526