circRNA basic information
circBase ID: hsa_circ_0089153
Name: hsa_circ_NUP214
Synonym: circNUP214
Host Gene: hsa-miR-145
 
 
 
Disease basic information
DO ID:
 1781
DO name: thyroid gland cancer
Disease details: thyroid cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: normal human thyroid follicular epithelial cells (K-1, TPC-1, SW579), human thyroid cancer cells (FTC133)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: ZEB2
Associated microRNA: hsa-miR-145
Biological function: increased cell proliferation, migratory, and invasive
Molecular mechanism: sponges hsa-miR-145 to promote the expression of ZEB2
Survival: -
Supported No.:
 1
Description:

circNUP214 may play an oncogenic role in PTC by acting as a sponge for miR-145, leading to upregulation of ZEB2.
Other information
Title:

CircNUP214 sponges miR-145 to promote the expression of ZEB2 in thyroid cancer cells.

Journal: Biochem Biophys Res Commun
Published: 2018/11/13
PubMed ID: 30415780