circRNA basic information
circBase ID: -
Name: hsa_circ_PAN3
Synonym: circPAN3
Host Gene: hsa-miR-153-5p, hsa-miR-183-5p
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human AML cells (THP-1)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
DN
Associated gene: XIAP
Associated microRNA: hsa-miR-153-5p, hsa-miR-183-5p
Biological function: -
Molecular mechanism: hsa-miR-153-5p/hsa-miR-183-5p-XIAP axis
Survival: -
Supported No.:
 2
Description:

Our findings provide evidence that circPAN3 can be a valuable indicator for predicting clinical efficacy of chemotherapy in AML patients and also can serve as a potential target for reversing drug resistance in AML.
Other information
Title:

CircPAN3 mediates drug resistance in acute myeloid leukemia through the miR-153-5p/miR-183-5p-XIAP axis.

Journal: Exp Hematol
Published: 2018/11/6
PubMed ID: 30395908