circRNA basic information
circBase ID: hsa_circ_0136666
Name: hsa_circ_PRKDC
Synonym: -
Host Gene: hsa-miR-136
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human CRC cell lines (LoVo, SW480, HCT116, SW620, HT29, HCT8, DLD1), normal colon epithelial cell line (FHC)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: SH2B1
Associated microRNA: hsa-miR-136
Biological function: promote cell proliferation and invasion
Molecular mechanism: sponging hsa-miR-625 and hsa-miR-892b
Survival: poor
Supported No.:
 4
Description:

Our data suggested that hsa_circ_0136666 could promote CRC cell progression via the miR-136/SH2B1 axis, elucidating a novel approach to improve the effectiveness of CRC treatment.
Other information
Title:

Hsa_circ_0136666 promotes the proliferation and invasion of colorectal cancer through miR-136/SH2B1 axis.

Journal: J Cell Physiol
Published: 2018/10/30
PubMed ID: 30370521