circRNA basic information
circBase ID: -
Name: -
Synonym: circ_104075
Host Gene: hsa-miR-582-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: liver cancer cell lines (Bel-7402, SMMC-7721, Huh7, HepG2, Hep1, Bel-7404), hepatocyte lines (THLE-3, HL-7702)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: YAP, HNF4a
Associated microRNA: hsa-miR-582-3p
Biological function: -
Molecular mechanism: HNF4a bound to the -1409 to -1401 region of the circ_104075 promoter to stimulate the expression of circ_104075. Moreover, circ_104075 acted as a ceRNA to upregulate YAP expression by absorbing hsa-miR-582-3p.
Survival: -
Supported No.:
 1
Description:

circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma.
Other information
Title:

circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma.

Journal: Cell Death Dis
Published: 2018/10/27
PubMed ID: 30361504