circRNA basic information
circBase ID: -
Name: hsa_circ_FBXW12
Synonym: circ-FBXW12
Host Gene: hsa-miR-31-5p
 
 
 
Disease basic information
DO ID:
 9743
DO name: diabetic neuropathy
Disease details: diabetic nephropathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human mesangial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LIN28B
Associated microRNA: hsa-miR-31-5p
Biological function: Circ-FBXW12 knockdown suppressed cell proliferation, arrested cell cycle, reduced extracellular matrix (ECM) production and oxidative stress in HG-induced HMCs.
Molecular mechanism: Circ-FBXW12 was identified as the sponge for miR-31-5p, which then directly targeted LIN28B.
Survival: -
Supported No.:
 1
Description:

Circ-FBXW12 knockdown suppressed HG-induced HMC growth, inflammation, ECM accumulation and oxidative stress by regulating miR-31-5p/LIN28B axis.
Other information
Title:

Circ-FBXW12 aggravates the development of diabetic nephropathy by binding to miR-31-5p to induce LIN28B.

Journal: Diabetol Metab Syndr
Published: 2021/12/6
PubMed ID: 34863268