circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circ_101280
Host Gene: hsa-miR-375
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cell lines (HepG2, SMMC-7721, SK-HEP-1, SNU-398), normal liver cell line (MIHA), human renal epithelial cell line (HEK-293T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: JAK2
Associated microRNA: hsa-miR-375
Biological function: promote cell proliferation and inhibit cell apoptosis
Molecular mechanism: sponging hsa-miR-375 and upregulating JAK2
Survival: -
Supported No.:
 1
Description:

both the in vitro and in vivo studies revealed that hsa_circ_101280 largely facilitated the tumorigenesis of HCC, characterized by the promoted proliferation and suppressed apoptosis of HCC cells, by sponging miR-375 and upregulating JAK2.
Other information
Title:

Hsa_circ_101280 promotes hepatocellular carcinoma by regulating miR-375/JAK2.

Journal: Immunol Cell Biol
Published: 2018/10/12
PubMed ID: 30302825