circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: -
Host Gene: hsa-miR-145-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MCF7, MDA-MB-231
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: p70S6K1
Associated microRNA: hsa-miR-145-5p
Biological function: promotes breast cancer cell growth, migration, and invasion
Molecular mechanism: elevating p70S6K1 via sponging hsa-miR-145-5p
Survival: poor
Supported No.:
 2
Description:

These data suggest that circZNF609 contributes to breast cancer progression, at least partly, by modulating the miR-145-5p/p70S6K1 axis, and it may be a potential therapeutic target for breast cancer.
Other information
Title:

CircZNF609 promotes breast cancer cell growth, migration, and invasion by elevating p70S6K1 via sponging miR-145-5p.

Journal: Cancer Manag Res
Published: 2018/10/6
PubMed ID: 30288120